MSc Thesis: Targeted Alpha Therapy

RaySearch develops innovative software solutions to improve cancer care. Over 1200 clinics in more than 54 countries use RaySearch software to improve treatments and quality of life for patients. RaySearch was founded in 2000 and is listed on Nasdaq Stockholm. The headquarters is located in Stockholm, with subsidiaries in the US, Europe, Asia and Australia & New Zealand. Today we are more than 485 employees with a common vision of improving cancer care with innovative software. Our great staff is crucial for our success and we offer a fantastic working environment in modern offices, flexibility and good opportunities for development. We believe in equal opportunities, value diversity and work actively to prevent discrimination. Are you curious about the physics behind targeted cancer treatments? Want to combine programming, imaging, and physics to explore new ways of improving cancer care? Then this thesis project could be for you. Project description Targeted Alpha Therapy (TAT) is an emerging cancer treatment that delivers highly localized radiation to tumour cells using alpha-emitting radionuclides. Promising early clinical results and a need for better treatments for advanced cancer have driven rapid growth in the field. A key challenge in TAT is patient-specific dosimetry. Although absorbed dose can be estimated using SPECT imaging, direct imaging of alpha emitters is often challenging due to low photon yields, limited image quality, and daughter radionuclide redistribution. An alternative is surrogate PET imaging using a related radiopharmaceutical, although this approach relies on simplifying assumptions. Another challenge is that absorbed dose alone may not fully describe the biological effects of alpha radiation. Because alpha particles produce dense ionization tracks and complex DNA damage, the relationship between dose and biological effect differs from conventional photon radiotherapy. Microdosimetric models such as the Microdosimetric Kinetic Model (MKM) offer a framework for translating physical dose distributions into biologically relevant treatment metrics. The MSc project will prototype image-based dosimetry workflows for TAT in RayStation. The work includes dosimetry based on post-treatment SPECT or surrogate PET imaging, voxel-based dose calculations, and potentially the integration of the Microdosimetric Kinetic Model (MKM). The long-term goal is to support biologically informed TAT treatment planning. Your profile We are looking for a curious master's student who wants to work where physics meets cancer care. You enjoy combining programming with careful experiments, and you look critically at results instead of taking them at face value. You are independent and well organized, and you can explain your findings clearly to both software engineers and medical physicists.

• Ongoing master's studies in engineering physics, medical physics, computer science, applied mathematics or a related field
• Coursework or project experience in physics
• Good programming skills in Python, C++ or C#
• Fluent written and spoken English

Application Please apply to the position through the link below. Selection and interviews will be ongoing. We do not accept applications by e-mail. Application Link.