Clinical Project Manager

Enara Bio is a science-led immunotherapy company developing novel T-cell directed cancer therapies. Using our proprietary EDAPT platform, we discover Dark Antigens, a new class of cancer-specific targets identified from genomic dark matter, and develop next-generation therapies including TCR-directed agents and bispecific T-cell engagers. Our lead programme, ENA101, targets DARKFOX, a novel Dark Antigen highly prevalent across solid tumours. Based in Oxford, UK, Enara Bio is backed by a strong syndicate of life science investors including RA Capital, Pfizer Ventures, M Ventures, Samsara BioCapital, SV Health Investors, and the Francis Crick Institute. Role Overview Enara Bio is seeking an experienced, detail-oriented Clinical Project Manager (CPM) to lead the operational execution of clinical trials within our growing pipeline, beginning with our first-in-human ENA101 study. Reporting to the Head of Clinical Operations, the CPM will translate clinical operations strategy into detailed study plans and drive day-to-day delivery, working closely with CROs, vendors, and cross-functional partners to ensure studies are delivered on time, within budget, and to the highest quality and compliance standards. The ideal candidate is a proactive, hands-on project manager with clinical trial delivery experience, comfortable operating in a fast-paced biotech environment. Location: Enara is based in Oxford, UK, and offers a flexible option for hybrid work for this position. Candidates must be able to work effectively within business hours that overlap with both UK and US East Coast teams. Reports to: Head of Clinical Operations Level: Manager / Senior Manager Key Responsibilities - Own day-to-day operational execution of assigned clinical trial(s), from start-up through close-out. - Develop and maintain integrated project plans, timelines, risk logs, and issue trackers. - Act as the primary operational point of contact for CROs and clinical vendors. - Monitor and report on study milestones, enrolment, and data quality/performance metrics. - Oversee CRO and vendor performance against contracted scope, budget, and KPIs; manage change orders. - Coordinate cross-functional input from Regulatory, Biometrics, Safety, CMC, and QA to keep studies on track. - Support site selection, feasibility assessment, and site activation/start-up activities. - Manage study budgets, forecasts, and vendor invoicing/reconciliation. - Ensure trial conduct complies with the protocol, ICH-GCP, and company SOPs. - Oversee Trial Master File completeness and support inspection readiness. - Escalate risks and issues to the Head of Clinical Operations with clear mitigation options. - Limited domestic/international travel as required to support site and vendor oversight. Qualifications and experience required - 5+ years' experience in clinical operations/project management within biotech, pharma, or a CRO. - Experience managing global or multi-region clinical trials; early-phase oncology experience preferred. - Working knowledge of ICH-GCP and applicable regulatory requirements (FDA, EMA, MHRA). - Demonstrated experience overseeing CRO and vendor performance and budgets. - Strong organisational, budget management, and risk management skills, with close attention to detail. - Excellent written and verbal communication; able to work cross-functionally in a fast-paced biotech setting. - Project management certification (e.g. PMP) is a plus. Further information: The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos: Empowerment: We promote autonomy across Enara rejecting conventional hierarchy. We engage each other through transparency, collaboration and trust. We each take action with a deep sense of personal and shared accountability. Courage: We push boundaries in all that we do to deliver on our purpose. We make bold decisions, embrace risk and tackle challenges to advance our novel science. Courage is essential for everything we do. Humility: We are proud of and excited by our novel science, but we acknowledge that we cannot know everything. Our curiosity drives us to continually learn from each other & the outside world irrespective of our role or title. We give and receive feedback with no room for ego. Growth: We invest in our people, culture and community to foster belonging as a foundation for success. We embrace individual development to create deeper personal fulfilment and drive stronger collective impact. We offer a competitive salary, commensurate with qualifications and experience, together with a comprehensive benefits package appropriate to the successful candidate's location. Applicants must be legally authorised to work in the country in which they reside and where employment is intended. Successful candidates will be required to provide evidence of their right to work in accordance with local requirements. Enara Bio is an equal opportunity employer. We are committed to fostering a diverse and inclusive workplace where all employees and applicants are treated fairly and with respect, irrespective of any characteristic protected by applicable law.